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KMID : 1161420110140040353
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Journal of Medicinal Food
2011 Volume.14 No. 4 p.353 ~ p.359
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Antihyperlipidemic Effect of Active Principle Isolated from Seed of Eugenia jambolana on Alloxan-Induced Diabetic Rabbits
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Sharma Suman B.
Tanwar Reenu S.
Nasir Afreena
Prabhu Krishna M.
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Abstract
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Diabetes is accompanied by lipid abnormalities, which contribute significantly to cardiovascular morbidity and mortality in diabetic patients. We previously demonstrated the potent antihyperglycemic activity of the active principle (fraction II from Sephadex LH 20 chromatography [LH II]) isolated from ethanolic seed extract of Eugenia jambolana in diabetic rabbits. In the present study, the efficacy of LH II was evaluated for its hypolipidemic activity in alloxan-induced mildly diabetic (MD) and severely diabetic (SD) rabbits. Phytochemical investigation of LH II by various structural spectra showed the presence of saturated fatty acid, Δ5 lipid, and sterol. Oral administration of LH II (10?mg/kg of body weight) for 21 days resulted in improved glycemic control in both MD and SD rabbits. After treatment with LH II, serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, and the total cholesterol/high-density lipoprotein cholesterol ratio were significantly improved. LH II also resulted in significant (P?
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KEYWORD
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alloxan, diabetes, Eugenia jambolana, hypolipidemic
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